A medicament for use in the treatment of a disease comprising administration on one to ten occasions daily using a hand held medicine dosing and dispensing device (10) comprising a housing (12) including a storage chamber (14) to store discrete units of medicine (16). The dispensing device (10) further includes a feed assembly (18) located between the storage chamber (14) and a dispenser (20) to feed individual units of medicine (16) from the storage chamber (14) to the dispenser (20). An impacter (22) is operably associated with the storage chamber (14) to agitate units of medicine (16) stored in the storage chamber (14). The impacter (22) includes a rigid element (24) fixedly connected at or towards one end (26) to a wall (28) of the storage chamber (14) and operably associated at or towards a second end (30) with an actuating mechanism (32) that deflects the second end (30) of the impacter (22) towards the wall (28) of the storage chamber (14) to strain the impacter (22) such that, when released, the strained impacter (22) moves towards the interior (34) of the storage chamber (14) and impacts against the units of medicine (16).
