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3,4-二取代的1H-吡唑化合物及其作為細胞周期蛋白依賴性激酶(CDK)和糖原合成酶激酶-3(GSK-3)調節劑的用途
专利权人:
ASTEX THERAPEUTICS LIMITED
发明人:
BERDINI, VALERIO,O'BRIEN, MICHAEL, ALISTAIR,CARR, MARIA, GRAZIA,EARLY, THERESA, RACHEL,GILL, ADRIAN, LIAM,TREWARTHA, GARY,WOOLFORD, ALISON, JO-ANNE,WOODHEAD, ANDREW, JAMES,WYATT, PAUL, GRAHAM,OBRIEN, MICHAEL, ALISTAIR
申请号:
HK06110511.3
公开号:
HK1090041B
申请日:
2006.09.21
申请国别(地区):
HK
年份:
2012
代理人:
摘要:
The invention provides compounds of the formula (0) or salts or tautomers or N-oxides or solvates thereof for use in the prophylaxis or treatment of disease states and conditions such as cancers mediated by cyclin-dcpcndcnt kinase and glycogen synthase kinase-3. In formula (0): X is a group R 1 -A-NR 4 - or a 5- or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO 2 , C=O, NR g (C=O) or O(C=O) wherein R g is hydrogen or C 1-4 hydrocarbyl optionally substituted by hydroxy or C 1-4 alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; R 1 is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C 1-8 hydrocarbyl group optionally substituted by one or more substituents selected from halogen (e.g. fluorine), hydroxy, C 1-4 hydrocarbyloxy, amino, mono- or di-C 1-4 hydrocarbylamino, and carbocyclic or heterocyclic groups having from 3 to 12 ring members, and wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected from O, S, NH, SO, SO 2 ; R 2 is hydrogen; halogen; C 1-4 alkoxy (e.g. methoxy); or a C 1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C 1-4 alkoxy (e.g. methoxy); R 3 is selected from hydrogen and carbocyclic and heterocyclic groups having from 3 to 12 ring members; and R 4 is hydrogen or a C 1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C 1-4 alkoxy (e.g. methoxy).
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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