Jayne Elizabeth Curry,John Francis Lyons,Matthew Simon Squires,Neil Thomas Thompson,Kyla Merriom Thompson,Paul Graham Wyatt
申请号：
US12752772
公开号：
US08404718B2
申请日:
2010.04.01
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention provides a combination comprising a cytotoxic compound, a signalling inhibitor, an ancillary agent, or two or more further anti-cancer agents, and a compound having the formula (Ib):or salts or tautomers or N-oxides or solvates thereofwhereinX is a group R1-A-NR4—A is a bond, C═O, NRg(C═O) or O(C═O) wherein Rg is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxyY is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in lengthR1 is a carbocyclic or heterocyclic group having from 3 to 12 ring members or a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from fluorine, hydroxy, C1-4 hydrocarbyloxy, amino, mono- or di-C1-4 hydrocarbylamino, and carbocyclic or heterocyclic groups having from 3 to 12 ring members, and wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected from O, S, NH, SO, SO2R2 is hydrogen halogen C1-4 alkoxy (e.g. methoxy) or a C1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C1-4 alkoxy (e.g. methoxy)R3 is selected from carbocyclic and heterocyclic groups having from 3 to 12 ring members andR4 is hydrogen or a C1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C1-4 alkoxy (e.g. methoxy).
