PROBLEM TO BE SOLVED: To provide a Tie2 activator, a neovascularization inhibitor, an agent for blood vessel maturation, an agent for blood vessel normalization, and a blood vessel stabilizer which have an excellent Tie2 activating action, neovascularization inhibitory action, blood vessel maturation action, blood vessel normalization action, and blood vessel stabilization action, and have high safety, and to provide a pharmaceutical composition.SOLUTION: The invention provides a Tie2 activator, a neovascularization inhibitor, an agent for blood vessel maturation, an agent for blood vessel normalization, and a blood vessel stabilizer which contain as an active ingredient at least one selected from Viburnum Macrocephalum Fort extract, acteoside, Tilia miqueliana Maxim. extract, and Aesculus hippocastanum L. extract, and a pharmaceutical composition containing at least any of them.【課題】優れたＴｉｅ２活性化作用、血管新生抑制作用、血管の成熟化作用、血管の正常化作用、及び血管の安定化作用を有する安全性の高いＴｉｅ２活性化剤、血管新生抑制剤、血管の成熟化剤、血管の正常化剤、及び血管の安定化剤、並びに医薬品組成物の提供。【解決手段】ケイカの抽出物、アクテオシド、ボダイジュの抽出物及びマロニエの抽出物から選択される少なくとも１種を有効成分として含有するＴｉｅ２活性化剤、血管新生抑制剤、血管の成熟化剤、血管の正常化剤、及び血管の安定化剤、並びにこれらの少なくともいずれかを含有する医薬品組成物である。【選択図】なし
