KIRSHNER Jessica R.,MACDONALD Douglas,THURSTON Gavin,MARTIN Joel H.,DELFINO Frank,NITTOLI Thomas,KELLY Marcus
申请号：
SI201530830
公开号：
SI3126388T1
申请日:
2015.03.10
申请国别(地区):
SI
年份:
2019
代理人:
摘要：
The present invention provides antibodies that bind to the class III variant of EGFR (EGFRvIII) and methods of using the same. According to certain embodiments, the antibodies of the invention bind human EGFRvIII with high affinity. The antibodies of the invention may be fully human antibodies. The invention includes anti-EGFRvIII antibodies conjugated to a cytotoxic agent, radionuclide, or other moiety detrimental to cell growth or proliferation. The antibodies of the invention are useful for the treatment of various cancers.
