Jessica R. KIRSHNER,Douglas MACDONALD,Gavin THURSTON,Joel H. MARTIN,Frank DELFINO,Thomas NITTOLI,Marcus KELLY
申请号：
US14643886
公开号：
US20150259423A1
申请日:
2015.03.10
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention provides antibodies that bind to the class III variant of EGFR (EGFRvIII) and methods of using the same. According to certain embodiments, the antibodies of the invention bind human EGFRvIII with high affinity. The antibodies of the invention may be fully human antibodies. The invention includes anti-EGFRvIII antibodies conjugated to a cytotoxic agent, radionuclide, or other moiety detrimental to cell growth or proliferation. The antibodies of the invention are useful for the treatment of various cancers.
