Methods of editing a single nucleotide polymorphism using programmable base editor systems

• 收藏
• 分享

专利权人:

Beam Therapeutics Inc.

发明人:

PETROSSIAN, Natalie,GEHRKE, Jason Michael

申请号：

AU2020279751

公开号：

AU2020279751A1

申请日:

2020.05.20

申请国别(地区):

AU

年份:

2021

代理人:

摘要：

Described are compositions and methods for altering mutations associated with Rett Syndrome (RETT). Provided herein are compositions and methods of using base editors (e.g., ABE8) comprising a polynucleotide programmable nucleotide binding domain and a nucleobase editing domain in conjunction with a guide polynucleotide. Also provided herein are base editor systems for editing nucleobases of target nucleotide sequences.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/