Espiropiperidina refers to a compound of formula (i) where R1 is H, F and chlorine R2 is H, alkyl c1-3, CF3, OCH3, H F and chlorine R3 and R4 c1-3 alkyl and R4A are independently h, OCH3, c1-3 alkyl, and NF3 Fluorine R5 is H or C? CCh3 X is CH2 CH (R3) -, - C (R3) = CH - (R7), - N and - CH2 - CH2 - C (o) R7 is H, alkyl and phenyl c1-3 Preferred compounds are: acid (3S) - 3 - (4 - ((4 - (1 - spiro [h inden - 1Piperidin] - 4 - 1 - methyl) benzyl] oxy] phenyl) - 4 - inoico hex acid (3S) - 3 - [4 - ((4 - ((1 - methyl - 1, 1 - dihydro - spiro [h] - indole - piperidin 3,4 - 1 - yl) methyl] phenyl benzyl}) oxy] - 4 - inoico hex among others. It also relates to a Pharmaceutical composition. Said Compound Is 40 Receptor Modulator coupled to G Protein (RPG - 40), being useful in the treatment of DiabetesSE REFIERE A UN COMPUESTO DE ESPIROPIPERIDINA DE FORMULA (I) DONDE: R1 ES H, F Y CLORO R2 ES H, ALQUILO C1-3, CF3, OCH3, F Y CLORO R3 ES H Y ALQUILO C1-3 R4 Y R4a SON INDEPENDIENTEMENTE H, OCH3, ALQUILO C1-3, CF3 Y FLUOR R5 ES H O C?CCH3 X ES CH(R3)CH2-, -C(R3)=CH-, -N(R7)CH2- Y -C(O)CH2- R7 ES H, ALQUILO C1-3 Y FENILO SON COMPUESTOS PREFERIDOS: ACIDO (3S)-3-(4-{[4-(1H-ESPIRO[INDEN-1,4-PIPERIDIN]-1-ILMETIL)BENCIL]OXI}FENIL)HEX-4-INOICO ACIDO (3S)-3-[4-({4-[(1-METIL-1,2,-DIHIDRO-1H-ESPIRO[INDOL-3,4-PIPERIDIN]-1-IL)METIL]BENCIL}OXI)FENIL]HEX-4-INOICO ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES MODULADOR DEL RECEPTOR 40 ACOPLADO A LA PROTEINA G (RPG-40), SIENDO UTIL EN EL TRATAMIENTO DE LA DIABETES
