Jay Edward WROBEL,Allen B. REITZ,Jeffery Claude PELLETIER,Garry Robert SMITH,Haiyan BIAN
申请号：
HK18108642
公开号：
HK1248706A1
申请日:
2018.07.04
申请国别(地区):
HK
年份:
2018
代理人:
摘要：
Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process.
