REITZ Allen B.;PELLETIER Jeffery Claude;SMITH Garry Robert;BIAN Haiyan;BIOHAVEN PHARMACEUTICAL HOLDING COMPANY LTD.;WROBEL Jay Edward
发明人:
WROBEL Jay Edward,REITZ Allen B.,PELLETIER Jeffery Claude,SMITH Garry Robert,BIAN Haiyan
申请号：
IL25398917
公开号：
IL253989D0
申请日:
2017.08.14
申请国别(地区):
IL
年份:
2017
代理人:
摘要：
Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process.
