Garry Robert Smith,Allen B. Reitz,Mark McDonnell,Suzie Chen,Matthew Douglas Vera,Benjamin Eric Blass,Jeffrey Claude Pelletier,Venkata Naga Velvadapu,Jay Edward Wrobel
申请号：
US14385551
公开号：
US20150045401A1
申请日:
2013.03.15
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process.
