A computer-implemented method for generating an assessment of traumatic brain injury (TBI) includes a TBI assessment computer receiving structural imaging data acquired by performing a structural imaging scan on an individual and generating a structural imaging score based on the structural imaging data. The TBI assessment computer receives functional imaging data acquired by performing a functional imaging scan on the individual and generates a functional imaging score based on the functional imaging data. The TBI assessment computer also receives diffusion imaging data acquired by performing a diffusion imaging scan on the individual and generates a diffusion imaging score based on the diffusion imaging data. Based on the structural imaging score, the functional imaging score, and the diffusion imaging score, the TBI assessment computer generates a TBI assessment score.