TENGLER, MARK,TASKEY, PAUL,LOCKHART, DANIEL,MCMAHEN, RUSSELL LEE
申请号:
CA2599585
公开号:
CA2599585C
申请日:
2006.02.24
申请国别(地区):
CA
年份:
2014
代理人:
摘要:
The present invention includes compositions and methods for the controlledrelease of active agents in a shelf-stable liquid formulation by blending oneor more controlled release microbeads comprising one or more active agents,preparing a dense, thixotropic solution having a density that is at, or about,the density of the one or more microbeads comprising a thixotropic agent,water and one or more preservatives under conditions that reduce bubbleformation and mixing the microbeads and the thixotropic solutions in a mixerthat lacks scraping paddles.