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Compositions and methods of making sustained release liquid formulations
专利权人:
NEOS THERAPEUTICS; LP
发明人:
Mcmahen, Russell Lee,Taskey, Paul,Lockhart, Daniel,Tengler, Mark
申请号:
AU2006218830
公开号:
AU2006218830B2
申请日:
2006.02.24
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
The present invention includes compositions and methods for the controlledrelease of active agents in a shelf-stable liquid formulation by blending oneor more controlled release microbeads comprising one or more active agents,preparing a dense, thixotropic solution having a density that is at, or about,the density of the one or more microbeads comprising a thixotropic agent, waterand one or more preservatives under conditions that reduce bubble formationand mixing the microbeads and the thixotropic solutions in a mixer that lacksscraping paddles.
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