SCHWAB, Wilfried (DE),ШВАБ Вильфрид (DE),BIRKMANN, Alexander (DE),БИРКМАНН Александр (DE),VOEGTLI, Kurt (CH),ФЕГТЛИ Курт (CH),HAAG, Dieter (CH),ХААГ Дитер (CH),LENDER, Andreas (DE),ЛЕНДЕР Андреас (DE)
申请号：
RU2017114501
公开号：
RU0002669388C1
申请日:
2012.09.26
申请国别(地区):
RU
年份:
2018
代理人:
摘要：
The present invention relates to a kind of improved and shorten synthesis N- [5-(Amino-sulfonyl) -4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4- (2- pyridyl groups and)Phenyl] acetamide and above-mentioned mesylate monohydrate and its organic tin compound and mesylate monohydrate N- [5- are but avoided using ylboronic acid derivative or the toxic borolane of salt reagent(Salt)Amino-sulfonyl -4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4- (2- pyridyl groups and phenyl] acet-amide)Long-time stability with the growth being proved simultaneously release dynamics from pharmaceutical composition.
