SCHWAB WILFRIED,BIRKMANN ALEXANDER,VÖGTLI KURT,HAAG DIETER,LENDER ANDREAS,GRUNENBERG ALFONS,KEIL BIRGIT,REHSE JOACHIM
申请号：
NZ71886712
公开号：
NZ718867A
申请日:
2012.09.26
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
The present disclosure relates to an improved and shortened synthesis of N-[5- (aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acet-amide and the mesylate monohydrate salt thereof by using boronic acid derivatives or borolane reagents while avoiding toxic organic tin compounds and to the mesylate monohydrate salt of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N- methyl-2-[4-(2-pyridinyl)phenyl]acet-amide which has demonstrated increased long term stability and release kinetics from pharmaceutical compositions.
