The present invention provides a slowly mouth saliva dissolving tablet comprising fluconazole which has superior buccal mucosal flux properties, which may be used for the treatment of oropharyngeal and esophageal candidiasis (oral candidiasis) of HIV and non HIV patients, cancer patients of fungal infection. Therefore, the slowly mouth saliva dissolving fluconazole tablet, by wet granulation method in the invention is able to continuously and stably release drug in during a long time, as well as maintain effective and safe drug concentration, unit dosage form and for both local and systemic action.
