VIVEKANANDA M. VRUDHULA,SENLIANG PAN,RAMKUMAR RAJAMANI,SUSHEEL JETHANAND NARA,MAHESWARAN SIVASAMBAN KARATHOLUVHU,TARUN KUMAR MAISHAL,JONATHAN L. DITTA,CAROLYN DIANE DZIERBA,JOANNE J. BRONSON,JOHN E. M
申请号：
ARP130102716
公开号：
AR093758A1
申请日:
2013.07.31
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Claim 1: A compound characterized in that it has formula (1) or a pharmaceutically acceptable salt thereof, wherein R¹ is selected from hydrogen, alkenyl C₂₋₄,C₁₋₃ alkoxy,C₁₋₃alkoxy C₁₋₃alkyl,1. Apartment c83218331；alquil C amino arilalquilo Ccycloalkyl C₃₋₆,cycloalkyl C₃₋₆alkyl C₁₋₃,C₁₋₃ haloalkyl and C₁₋₃ hydroxyalkyl；R² is selected from hydrogen, C₁₋₃ alkoxy,alcoxi C carbonilamino alquilo Calkyl C₁₋₃amino, alkyl C₁₋₃carbonylamino, amino, arylamino, arylcarbonylamino, cycloalkyl C₃₋₆amino, cycloalkyl C₃₋₆carbonylamino, cycloalkyloxy C₃₋₆,halo, haloalkoxy C₁₋₃,Halogenated tar c83218323；haloalkyl C₂₋₃amino, haloalkyl C₂₋₃carbonylamino, hydroxy and phenyl-alkyl C₁₋₃amino, wherein the phenyl is optionally substituted with a C₁₋₃ alkoxy group；R³ and R⁴ are independently selected from hydrogen, C₁₋₄ alkoxy,C₁₋₃alkoxy C₁₋₃alkyl,alcoxi C carbonilo alquilo Calquil C sulfonilo aminocarbonilo ciano cicloalquilo Cdi (alquil C) aminocarbonilo halo haloalcoxi CHalogenated tar c83218323；heteroaryl, hydroxy, C₁₋₃ hydroxyalkyl, and phenyl optionally substituted with a halo group； R⁵ is C₁₋₃-Y alkyl or C₂₋₈ alkyl,wherein C₂₋₈-alkyl is optionally substituted with 1, 2, 3 or 4 groups independently selected from C₁₋₃-alkoxy,a. Nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnny Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y；wherein the cycloalkyl is also optionally substituted with 1, 2 or 3 groups independently selected from C₁₋₃ alkoxy,1. Apartment c83218331；alquil C amino alcoxi C alquil C amino amino arilo arilalquilo Chalo, haloalkyl C₁₋₃,a. Keywords halogenated tar c833218331-83323； ammonia and water Xi； r739y r696；e. Combine with nitrogen atom to form a ring of 3-6 members, and select (2) from formula group；where n is 0, 1, 2 or 3； each R⁶ is independently selected from hydrogen, C₁₋₆ alkyl,aryl, arylalkyl C₁₋₃,cycloalkyl C₃₋₆,a. Halo and halogelo c8321c833183223；each R⁷ is independently selected from hydrogen,
