PROBLEM TO BE SOLVED: To provide a method for producing a tablet excellent in dispersibility of a sparingly water-soluble medicament without using hydrogen carbonate and carbonate.SOLUTION: There is provided a method for producing a tablet which comprises: a step of obtaining granulated granules by extrusion-granulating a mixture comprising a sparingly water-soluble medicament (A), at least one (B) of a sugar and a sugar alcohol, at least one (C) of a cationic surfactant and an anionic surfactant and a water-soluble polymer compound (D) in which the mass ratio represented by (B) component/(A) component is 0.1 to 3.5 and the mass ratio represented by (C) component/(A) component is 0.01 to 0.15 and a step of performing tableting using the granulated granules obtained.SELECTED DRAWING: NoneCOPYRIGHT: (C)2017,JPO&INPIT【課題】炭酸水素塩および炭酸塩を用いなくても、水難溶性薬物の分散性に優れる錠剤の製造方法の提供。【解決手段】水難溶性薬物(A)と、糖および糖アルコールの少なくとも一方(B)と、カチオン性界面活性剤およびアニオン界面活性剤の少なくとも一方(C)と、水溶性高分子化合物(D)とを含み、(B)成分/(A)成分で表される質量比が0.1~3.5であり、(C)成分/(A)成分で表される質量比が0.01~0.15である混合物を押出造粒して造粒顆粒を得る工程と、得られた造粒顆粒を用いて打錠する工程と、を有する、錠剤の製造方法。【選択図】なし
