SHAH, Manish S.,DIFALCO, Ray J.,SHAH MANISH S,DIFALCO RAY J
申请号：
ES08797716
公开号：
ES2692437T3
申请日:
2008.08.12
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
An oral pharmaceutical deterrent against abuse, comprising: an expansion layer comprising an expandable polymer； a barrier layer substantially covering the expansion layer and comprising a first polymer selected from the group consisting of: polyacrylates or copolymers thereof, poly (ethylene oxides), and polypropylenes, polycarbonates, and a diffusion layer, which it comprises a second polymer selected from the group consisting of: ethyl cellulose, acrylic or methacrylic polymers of quaternary ammonium, copolymers of acrylic or methacrylic esters, or mixtures thereof, and acrylic or methacrylic polymers, which substantially covers the barrier layer, wherein The diffusion layer is bonded to the spray barrier layer and then cured and comprises a drug that is substantially homogeneously distributed within the second polymer and diffuses from the diffusion layer into the gastrointestinal (GI) tract, where the drug is a central nervous system stimulant or depressant selected from the group consisting of agonis tas opioids, zaleplon, barbiturates, benzodiazepines and amphetamines, and where the composition is configured such that when the pharmaceutical composition is physically compromised and particles of the pharmaceutical composition containing the diffusion layer and the barrier layer are formed, the junction between the diffusion layer and the barrier layer within the particles is substantially preserved.Una composición farmacéutica oral disuasoria del abuso, que comprende: una capa de expansión que comprende un polímero expandible； una capa de barrera que cubre sustancialmente la capa de expansión y que comprende un primer polímero seleccionado del grupo que consiste en: poliacrilatos o copolímeros de los mismos, poli(óxidos de etileno), y polipropilenos, policarbonatos, y una capa de difusión, que comprende un segundo polímero seleccionado del grupo que consiste en: etilcelulosa, polímeros acrílicos o metacrílicos de amonio cuaternario, copolímeros de ésteres acr
