A compound selected from the compounds of Formula I and Formula IA: and pharmaceutically acceptable enantiomers, diastereomers, solvates and salts thereof having a ring A and a ring B, in which: ring A is optionally substituted with one or more of R shown as R20 and R21； G is CH or N； Q is C or N； X is CH or N, with the proviso that Q and X are not both N； Y is CH2, N (R3), C (= O), O, OCR9R9, S, S (= O) or S (O) 2； n1 is 0-2； n2 is 0-2； n3 is 1-2； R1 is a 6-membered monocyclic aryl, a 5-membered monocyclic heteroaryl or a 6-membered monocyclic heteroaryl, each of which may be optionally substituted with one or more members selected from R1a, R1b, R1c, R1d and R1e； each of R1a, R1b, R1c, R1d and R1e is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, halo, - NH2, -CN, -NO2, -C (= O) OH, -C (= O) OR10, -OCF3, -OR11, -OH, -SH, -SR11r S (O) 3H, -P (O) 3H2, -C (= O) NR9R9, -NR12R12, -S (O) 2NR9R9, -NR9S (O) 2CF3, - C (= O) NR9S (O) 2R9, -S (O) 2NR9C (= O) OR9, -S (O) 2NR9C (= O) NR9R9, -C (= O) NR9S (O) 2CF3, -C (= O) R11, -NR9C (= O) H, - NR9C (= O) R10, -OC (= O) R10, -OC (= O) NR9R9, -C (= NR14) NR9R9, -NHC (= NR14) NR14R14, -S (= O) R11, -S (O) 2R11, - NR9C (= O) OR8 and -NR9S (O2) R8, in that: (a) each of the alkenyl, alkynyl, cycloalkyl, aryl and heterocyclyl may be optionally substituted with one or more of R6； and (b) the alkyl may be optionally substituted with one or more of R7； R2 is cycloalkyl, aryl, heteroaryl, heterocyclyl, -S (O) 2R5, -C (= O) NR3R5, -C (= O) R5 or -C (= O) OR5, in which each of the cycloalkyl, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more of R6； R3 is hydrogen, alkyl, alkoxy, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl； R5 is alkyl, alkenyl, aryl, cycloalkyl, heteroaryl or heterocyclyl, each of which may be optionally substituted with one or more of R6； R6, in each case, is independently
