It is an object of the present invention to provide a retinal tissue rich in cone precursors and / or cone photoreceptor cells, retinal photoreceptor cell progenitor cells and / or retinal tissue rich in rod optic cells, and methods of their production.The retinal tissue from the early stage of development to the stage in which the appearance rate of the pyramidal photoreceptor progenitor cell becomes maximumI) the process of incubation in the medium containing the dorsal signal transduction of concentration to suppress the expression of the ventral markerA method of increasing the proportion of a pyramidal photoreceptor cell precursor cell and a pyramidal photoreceptor cell in a photoreceptor cell precursor cell and a photoreceptor cell contained in a retinal tissueOr (II) the process of incubation in the presence of a ventral signal transduction of concentration to promote the expression of the ventral markerA method of increasing the proportion of a rod cell precursor cell and a rod photoreceptor cell in a photoreceptor cell progenitor cell in a retinal tissue and a photoreceptor cell.本発明は、錐体視前駆細胞及び／又は錐体視細胞に富む網膜組織、桿体視細胞前駆細胞及び／又は桿体視細胞に富む網膜組織、及びそれらの製造方法等を提供することを課題とする。発生初期段階から錐体視細胞前駆細胞の出現率が極大になる段階までの網膜組織を、i)腹側マーカーの発現を抑制する程度の濃度の背側化シグナル伝達物質を含む培地で培養する工程を含む、網膜組織に含まれる視細胞前駆細胞及び視細胞中の錐体視細胞前駆細胞及び錐体視細胞の割合を増加させる方法、あるいはii)腹側マーカーの発現を促進する程度の濃度の腹側化シグナル伝達物質の存在下に培養する工程を含む、網膜組織に含まれる視細胞前駆細胞及び視細胞中の桿体視細胞前駆細胞及び桿体視細胞の割合を増加させる方法。
