PROCEDE D'AMPLIFICATION DE PHOTORECEPTEURS DE CONES OU PHOTORECEPTEURS DE BATONNETS A L'AIDE D'UN TRANSMETTEUR DE SIGNAL DE DORSALISATION OU UN TRANSMETTEUR DE SIGNAL DE VENTRALISATION
The present invention addresses the problem of providing a cone photoreceptor precursor cell and/or a retinal tissue rich in cone photoreceptors, a rod photoreceptor precursor cell and/or a retinal tissue rich in rod photoreceptors, and a method for manufacturing the same. The present invention is: i) a method for amplifying the ratio of cone photoreceptor precursor cells and cone photoreceptors in photoreceptor precursor cells and photoreceptors included in a retinal tissue, the method including a step for culturing the retinal tissue from an initial development stage until a stage at which the occurrence of cone photoreceptor precursor cells is at maximum in a medium including a dorsalization signal transmitter at a concentration sufficient to suppress expression of a ventral marker； or ii) a method for amplifying the ratio of rod photoreceptor precursor cells and rod photoreceptors in photoreceptor precursor cells and photoreceptors included in a retinal tissue, the method including a step for culturing the retinal tissue from an initial development stage until a stage at which the occurrence of rod photoreceptor precursor cells is at maximum in a medium including a dorsalization signal transmitter at a concentration sufficient to suppress expression of a ventral marker.
