PROCÉDÉ D'AMPLIFICATION DE PHOTORÉCEPTEURS DE CÔNES OU PHOTORÉCEPTEURS DE BÂTONNETS À L'AIDE D'UN TRANSMETTEUR DE SIGNAL DE DORSALISATION OU UN TRANSMETTEUR DE SIGNAL DE VENTRALISATION
RIKEN;SUMITOMO CHEMICAL COMPANY, LIMITED;Sumitomo Dainippon Pharma Co., Ltd.
发明人:
申请号：
EP18855704.5
公开号：
EP3683304A1
申请日:
2018.09.14
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
The present invention aims to provide a retinal tissue rich in cone photoreceptor precursors and/or cone photoreceptors, a retinal tissue rich in rod photoreceptor precursors and/or rod photoreceptors, and a production method thereof and the like. i) A method for increasing a proportion of a cone photoreceptor precursor and a cone photoreceptor in a photoreceptor precursor and a photoreceptor contained in a retinal tissue, including a step of culturing a retinal tissue, in an initial developmental stage to a stage where an emergence rate of a cone photoreceptor precursor reaches maximum, in a medium containing a dorsalization signal transmitter at a concentration sufficient to suppress expression of a ventral marker, or ii) a method for increasing a proportion of a rod photoreceptor precursor and a rod photoreceptor in a photoreceptor precursor and a photoreceptor contained in a retinal tissue, including a step of culturing a retinal tissue, in an initial developmental stage to a stage where an emergence rate of a cone photoreceptor precursor reaches maximum, in a medium containing a ventralization signal transmitter at a concentration sufficient to promote expression of a ventral marker.
