LI, BIN,LIN, FANG,CHEN, ZUOJIA,LI, ZHIYUAN,PAN, FAN
申请号：
EP11803163
公开号：
EP2591797A4
申请日:
2011.07.11
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
The present invention relates to regulatory factors for FOXP3 and regulatory T cells and application thereof. Specifically, the present invention relates to the use of an ubiquitination pathway-related factor, its agonist or antagonist in the preparation of a composition for regulating FOXP3, IL-2, and/or IFN-³ activity, in which the ubiquitination pathway-related factor is selected from: Toll-like receptor, ubiquitin ligase, pro-inflammatory cytokine family receptor, and/or its coding sequence. The new type of regulatory factors of the present invention can regulate regulatory T cells and immune system by regulating FOXP3, IL-2, and/or IFN-³ activity. The regulatory factors and their derivatives of the present invention can also be used as immunoadjuvant for treating or preventing major diseases (such as, infectious diseases and tumor, etc).
