GUEDAN CARRIO SONIA,CASCALLO PIQUERAS MANEL MARIA,ALEMANY BONASTRE RAMON
申请号：
IN9086/DELNP/2011
公开号：
IN2011DN09086A
申请日:
2011.11.21
申请国别(地区):
IN
年份:
2013
代理人:
摘要：
The invention is related to an oncolytic adenovirus that comprises a sequence encoding a hyaluronidase enzyme inserted in its genome. This adenovirus spreads more efficiently in the tumour mass and therefore the oncolytic effect is increased. Injecting the oncolytic adenovirus of the invention endovenously, tumour volume regressions are obtained. Therefore the oncolytic adenovirus of the present invention is useful for the treatment of a cancer or a pre-malignant state of cancer.
