FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE (IDIBELL);INSTITUT CATALA D'ONCOLOGIA
发明人:
Sònia GUEDAN CARRIó,Manel Maria CASCALLO PIQUERAS,Ramon ALEMANY BONASTRE
申请号：
HK18104062.5
公开号：
HK1244679A
申请日:
2018.03.23
申请国别(地区):
HK
年份:
2018
代理人:
摘要：
The invention is related to an oncolytic adenovirus that comprises a sequence encoding a hyaluronidase enzyme inserted in its genome. This adenovirus spreads more efficiently in the tumour mass and therefore the oncolytic effect is increased. Injecting the oncolytic adenovirus of the invention endovenously, tumour volume regressions are obtained. Therefore the oncolytic adenovirus of the present invention is useful for the treatment of a cancer or a pre-malignant state of cancer.
