FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE;FUNDACIO PRIVADA INSTITUT DINVESTIGACIO BIOMEDICA DE BELLVITGE;INSTITUT CATALA D'ONCOLOGIA
发明人:
Guedan Carrio, Sonia,Cascallo Piqueras, Manel Maria,Alemany Bonastre, Ramon
申请号：
AU2010244348
公开号：
AU2010244348B2
申请日:
2010.05.05
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
The invention relates to an oncolytic adenovirus that comprises a sequence that encodes a hyaluronidase enzyme inserted in the genome thereof. This adenovirus is distributed more efficiently through the mass of the tumour and consequently the oncolytic effect is enhanced. Endovenous injection of the oncolytic adenovirus of the invention gives rise to regressions in tumour volume. Therefore, the oncolytic adenovirus of the present invention can be used to treat cancer or a pre-malignant stage thereof.
