Drug composition is new consisting of hollow protein nanoparticles which enclose a drug substance and which present at their surface a tissue or cell specific antibody. ACTIVITY : Cytostatic Virucide. MECHANISM OF ACTION : Cell or tissue specific targeting of a therapeutic substance. The effect of intravenous administration of Hepatitis B virus (HBV) surface antigen (lacking preS region) nanoparticles enclosing ganciclovir and presenting anti-human epidermal growth factor receptor (EGFR) antibody on development of A431 human epidermal cancer cells and (for comparison) WiDr human colon cancer cells were implanted subcutaneously into nude rats. No test results provided.
