ALARGOVA, Rossitza G.,BILODEAU, Mark T.,DUNBAR, Craig A.,KADIYALA, Sudhakar,SHINDE, Rajesh R.,LIM SOO, Patrick,SWERYDA-KRAWIEC, Beata,WHITE, Brian H.,BAZINET, Patrick Rosaire,WOOSTER, Richard
申请号：
AU2018204037
公开号：
AU2018204037A1
申请日:
2018.06.07
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
#$%^&*AU2018204037A120180621.pdf#####Abstract Nanoparticles and micro-particles, and pharmaceutical formulations thereof, containing conjugates of an active 5 agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker have been designed. Such nanoparticles and micro-particles can provide improved temporospatial delivery of the active 10 agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious 15 diseases. 10157337_1 (GHMatters) P104768.AU.1 10/04/184/8 FIGURE 4 NCI-H69 xenograft study - 3000 S-9- Vehicle 0 2000 -+ Conjugate 14 2 mg/kg E Conjugate 10 nanopartice, 2 mg/kg >；+ DM1, O.8 mg/kg 1- 1000- a 0 -~ 0 10 20 30 40 60 60 70 80 90 100110 Days Dose given
