Rossitza G. Alargova,Mark T. Bilodeau,Craig A. Dunbar,Sudhakar Kadiyala,Rajesh R. Shinde,Patrick Lim Soo,Beata Sweryda-Krawiec,Brian H. White,Patrick Rosaire Bazinet,Richard Wooster
申请号：
US15652947
公开号：
US20180000959A1
申请日:
2017.07.18
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker have been designed. Such nanoparticles and microparticles can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.
