Alargova, Rossitza G.,Bilodeau, Mark T.,Dunbar, Craig A.,Kadiyala, Sudhakar,Shinde, Rajesh R.,Lim Soo, Patrick,Sweryda-Krawiec, Beata,White, Brian H.,Bazinet, Patrick Rosaire,Wooster, Richard
申请号：
AU2015284236
公开号：
AU2015284236B2
申请日:
2015.06.30
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
Nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker have been designed. Such nanoparticles and microparticles can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.
