The present invention falls within the field of the use of liposome preparations in the preparation of tumor drugs, and in particular relates to the construction and use of a multicellular targeting liposome. A single liposome comprises multiple antibodies against different cells and a liposome with a stable structure and long circulation characteristics in vivo is constituted by molecular self-assembly. The multicellular targeting liposome can sequentially or simultaneously bind to multiple different cells by means of the action of antibodies to promote the identification of, communication between, the cytotoxicity of, the pro-apoptosis or clearance of different cells, etc.
