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Use of Mutant Herpes Simplex Virus-2 for Cancer Therapy
专利权人:
发明人:
Xiaoliu Zhang,Xinping Fu
申请号:
US14622263
公开号:
US20150150920A1
申请日:
2015.02.13
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The present invention is directed to the composition and use of a modified Herpes Simplex Virus Type 2 (HSV-2) as a medicament in the treatment of cancer. The modified HSV-2 has fusogenic activity, and comprises a modified/mutated ICP10 polynucleotide encoding a polypeptide having ribonucleotide reductase activity and lacking protein kinase activity.
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中国工程科技知识中心
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