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PHARMACEUTICAL FORMULATION HAVING REVERSE THERMAL GELATION PROPERTIES FOR LOCAL DELIVERY OF NANOPARTICLES
专利权人:
发明人:
申请号:
EP15808134.9
公开号:
EP3226914A1
申请日:
2015.12.06
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
The present invention refers to a pharmaceutical formulation for injection comprising nanoparticles as in vivo diagnostics and therapeutics. The present invention relates to an injectable pharmaceutical formulation for human medicine and/or veterinary use, comprising 5% to 50% per weight of a poloxamer, 0.1 nM to 10.0 µM nanoparticles and water or an aqueous buffer, wherein the pharmaceutical formulation is liquid at 4°C - 30°C and forms a gel at about 37°C, their use as an in vivo marker and methods of their preparation. The inventive formulation is useful for local control and prevention of spreading/diffusion of nanoparticles, and thus allows full utilization of their quantum physics properties for example as a tool to enable surgical precision of tumor removal even without tumor specific epitope binding antibodies.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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