Leah E. Appel;Ronald A. Beyerinck;Avinash G. Thombre;Dwayne T. Friesen;Mark B. Chidlaw;Kelly L. Smith;William J. Curatolo
发明人:
Leah E. Appel,Ronald A. Beyerinck,Mark B. Chidlaw,William J. Curatolo,Dwayne T. Friesen,Kelly L. Smith,Avinash G. Thombre
申请号：
US12979278
公开号：
US09028870B2
申请日:
2010.12.27
申请国别(地区):
US
年份:
2015
代理人:
摘要：
A controlled release dosage form has a coated core with the core comprising a drug-containing composition and a water-swellable composition, each occupying separate regions within the core. The drug-containing composition comprises a low-solubility drug and a drug-entraining agent. The coating around the core is water-permeable, water-insoluble and has at least one delivery port therethrough. A variety of formulations having specific drug release profiles are disclosed.
