COMBINAISONS DE COMPOSES INHIBITEURS D'AKT ET D'AGENTS CHIMIOTHERAPEUTIQUES, ET PROCEDES D'UTILISATION

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专利权人:

INC.;GENENTECH

发明人:

LIN, KUI,NANNINI, MICHELLE,PUNNOOSE, ELIZABETH,SAMPATH, DEEPAK,WALLIN, JEFFREY,PATEL, PREMEL

申请号：

CA2831935

公开号：

CA2831935A1

申请日:

2012.03.30

申请国别(地区):

CA

年份:

2012

代理人:

摘要：

The invention provides combinations comprising a) compound of formula (I) or a pharmaceutically acceptable salt thereof wherein R1, R2, R5, R10, and A have any of the values defined in the specification； and b) one or more agents selected from 5-FU, a platinum agent, leucovorin, irinotecan, docetaxel, doxorubicin, gemcitabine, SN-38, capecitabine, temozolomide, paclitaxel, bevacizumab, pertuzumab, tamoxifen, rapamycin and lapatinib. The combinations are particularly useful for treating hyperproliferative disorders, such as cancer.

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