BACHA, JEFFREY A.; INC.;DELMAR PHARMACEUTICALS, INC.;DELMAR PHARMACEUTICALS;BROWN, DENNIS M.;STEINO, ANNE
发明人:
BACHA, JEFFREY A.,BROWN, DENNIS M.,STEINO, ANNE
申请号：
CA2985511
公开号：
CA2985511A1
申请日:
2016.05.12
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The use of dianhydrogalactitol provides a novel therapeutic modality for the treatment of non-small-cell lung carcinoma (NSCLC) and ovarian cancer, as well as other types of malignancy, including brain metastases of NSCLC. Dianhydrogalactitol acts as an alkylating agent on DNA that creates N7 methylation. Dianhydrogalactitol is effective in suppressing the growth of cancer stem cells and is active against tumors that are refractory to temozolomide, cisplatin, and tyrosine kinase inhibitors； the drug acts independently of the MGMT repair mechanism. Dianhydrogalactitol can be used together with other anti-neoplastic agents and can possess additive or super-additive effects.
