Kui Lin,Michelle Nannini,Elizabeth Punnoose,Deepak Sampath,Jeffrey Wallin,Premal Patel
申请号：
US15017315
公开号：
US09717730B2
申请日:
2016.02.05
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The invention provides combinations comprising a) compound of formula I:or a pharmaceutically acceptable salt thereof wherein R1, R2, R5, R10, and A have any of the values defined in the specification； and b) one or more agents selected from 5-FU, a platinum agent, leucovorin, irinotecan, docetaxel, doxorubicin, gemcitabine, SN-38, capecitabine, temozolomide, paclitaxel, bevacizumab, pertuzumab, tamoxifen, rapamycin and lapatinib. The combinations are particularly useful for treating hyperproliferative disorders, such as cancer.
