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Prodrugs of piperazine and substituted piperidine antiviral agents
专利权人:
BRISTOL-MYERS SQUIBB PHARMA COMPANY
发明人:
申请号:
IL21196111
公开号:
IL211961A
申请日:
2011.03.27
申请国别(地区):
IL
年份:
2013
代理人:
摘要:
This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection. wherein: X is C or N with the proviso that when X is N, R1 does not exist W is C or N with the proviso that when W is N, R2 does not exist V is C E is hydrogen or a pharmaceutically acceptable salt thereof and Y is selected from the group consisting of Also, this invention provides for intermediate Compounds II useful in making prodrug Compounds I. wherein: L and M are independently selected from the group consisting of C1-C6 alkyl, phenyl, benzyl, trialkylsilyl, -2,2,2-trichloroethoxy and 2-trimethylsilylethoxy.
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