Sing-Yuen SIT,Yan CHEN,Jie CHEN,Jacob SWIDORSKI,Brian Lee VENABLES,Ny SIN,Nicholas A. MEANWELL,Alicia REGUEIRO-REN,Richard A. HARTZ,Li XU,Zheng LIU
申请号：
US15344756
公开号：
US20170056420A1
申请日:
2016.11.07
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I:with X selected from C4-8 cycloalkyl, C4-8 cycloalkenyl, C4-9 spirocycloalkyl, C4-9 spirocycloalkenyl, C4-8 oxacycloalkyl, C4-8 dioxacycloalkyl, C6-8 oxacycloalkenyl, C6-8 dioxacycloalkenyl, C6 cyclodialkenyl, C6 oxacyclodialkenyl, C6-9 oxaspirocycloalkyl and C6-9 oxaspirocycloalkenyl ring, such that X is substituted with A, wherein A is —C1-6 alkyl-halo. These compounds are useful for the treatment of HIV and AIDS.
