Sit, Sing-Yuen,Chen, Yan,Chen, Jie,Swidorski, Jacob,Venables, Brian Lee,Sin, Ny,Meanwell, Nicholas A.,Regueiro-Ren, Alicia,Hartz, Richard A.,Xu, Li,Liu, Zheng
申请号：
AU2015243500
公开号：
AU2015243500B2
申请日:
2015.04.09
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: with X selected from C4-8 cycloalkyl, C4-8 cycloalkenyl, C4-9 spirocycloalkyl, C4-9 spirocycloalkenyl, C4-8 oxacycloalkyl, C4-8 dioxacycloalkyl, C6-8 oxacycloalkenyl, C6-8 dioxacycloalkenyl, C6 cyclodialkenyl, C6 oxacyclodialkenyl, C6-9 oxaspirocycloalkyl and C6-9 oxaspirocycloalkenyl ring, such that X is substituted with A, wherein A is &mdash；C1-6 alkyl-halo. These compounds are useful for the treatment of HIV and AIDS.
