Disclosed herein are methods of treating fibrotic disorders by administering compounds selective for CAPN1, CAPN2, and/or CAPN9 such that side effects, off pathway interactions, and/or toxicities are minimized. Such methods may, for example, minimize unintended effects of therapeutic compounds by providing dosing and dosage forms that minimize the level of unbound drug within the relevant tissues of a patient undergoing treatment.本發明揭示治療纖維化病症之方法，其係藉由投與對於CAPN1、CAPN2及/或CAPN9具有選擇性之化合物，使得副作用、路徑外相互作用及/或毒性減至最小。舉例而言，此方法可藉由提供進行治療之患者之有關組織內未結合藥物的量減至最小的劑量及劑型，將治療化合物的非預期效應減至最小。
