Long-cherished desire invention, the tissue characteristic disease remedy and/or method in order to control, and/or, offers the method in order it remedies or to control the damage which is selected from the group which consists of the keloid and the hypertrophic scar, that method although the polypeptide which includes the HSP20-related polypeptide, the damage which is selected from the group which consists of the keloid and the hypertrophic scar is controlled remedy and/or includes the fact that it prescribes to the individual which needs that at the effective quantity.本願発明は、線維性疾患を治療および/または抑制するための方法、および/または、ケロイド及び肥厚性瘢痕からなる群から選択される傷跡を治療または抑制するための方法を提供し、その方法は、HSP20関連ポリペプチドを含むポリペプチドを、ケロイド及び肥厚性瘢痕からなる群から選択される傷跡を治療および/または抑制するのに効果的な量でそれを必要とする個体に投与することを含む。