KEEFE, Anthony D.,WAGNER, Richard W.,CLARK, Matthew,ZHANG, Ying,GIKUNJU, Diana,CUOZZO, John,THOMSON, Heather
申请号：
ES13736185
公开号：
ES2672367T3
申请日:
2013.01.09
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound having the formula: ** Formula ** or a stereoisomer or a pharmaceutically acceptable salt, in which each R1, R2, R3, and R4 is independently N or CR5, in which each R5 is independently H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkyl-halo, C 1-6 alkoxy, C 2-6 alkyloxy, C 2-6 alkynyloxy, C 1-6 halo-alkoxy, (C 1-6 alkoxy 6) -C1-6 alkyl, C1-7 acyl, C1-7 acylamino, C1-7 acyloxy, C6-10 aryl, (C1-6 alkyls) -C6-10 aryl, amino, halogen, cyano, nitro, hydroxy , or carboxyl； A is H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-7 acyl, C1-12 heterocyclyl, carboxyl, -C (O) -NRA1RA2, or -NRA1- C (O) -RA2, in which each RA1 and RA2 is independently H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, or (C1-6 alkoxy) -C1-6 alkyl, or in which the combination of RA1 and RA2 can together form C1-12 heterocyclyl； X is ** Formula ** and in which each of Xa, Xb, and Xc is independently selected from O, S, NRX1, N, or CRX2； RX1 is H or C1-6 alkyl； and RX2 is H, halo, or C1-6 alkyl； L is -CH2-NZN1- or -CH2-O-, wherein each ZN1 is independently H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, or a protective group of N； each Z3a, Z3b, Z4, Z5a and Z5b is, independently, H, or C1-6 alkyl； and Y is bicyclic C1-12 heterocyclyl.Un compuesto que tiene la fórmula:**Fórmula** o un estereoisómero o una sal farmacéuticamente aceptable, en la que cada R1, R2, R3, y R4 es, independientemente, N o CR5, en la que cada R5 es, independientemente, H, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, halo-alquilo C1-6, alcoxi C1-6, alqueniloxi C2-6, alquiniloxi C2-6, halo-alcoxi C1-6, (alcoxi C1- 6)-alquilo C1-6, acilo C1-7, acilamino C1-7, aciloxi C1-7, arilo C6-10, (alq-C1-6)-arilo C6-10, amino, halógeno, ciano, nitro, hidroxi, o carboxilo； A es H, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, acilo C1-7, heterociclilo C1-12, carboxilo, -C(O)-NRA1RA2, o -NRA1- C(O)-RA2, en las que cada RA1 y RA2 es, independientemente, H, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, o (alcoxi C1-6)-alquilo C1-6, o en las
