AHMED, Mahbub,ASHALL-KELLY, Alexander,BLOOMFIELD, Graham Charles,GUERITZ, Louisa,MCKENNA, Jeffrey,MCKENNA, Joseph,MUTTON, Simon,PARMAR, Rakesh,SHEPHERD, Jon,WRIGHT, Paul
申请号：
ES13826624
公开号：
ES2650372T3
申请日:
2013.12.17
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of the formula (I), or a pharmaceutically acceptable salt thereof: ** Formula ** wherein R1 represents phenyl, cycloalkenyl (from 4 to 7 carbon atoms) or Het1, whose group R1 may be unsubstituted or substituted on one or two carbon atoms by substituents Ra, and may also be substituted on a nitrogen atom with a substituent Ra1； each Ra independently represents alkyl (from 1 to 4 carbon atoms), halogen, halo-alkyl (from 1 to 4 carbon atoms), cyano, hydroxy-alkyl (from 1 to 4 carbon atoms), alkoxy (from 1 to 4 4 carbon atoms), halo-alkoxy (from 1 to 4 carbon atoms), alkoxy (from 1 to 4 carbon atoms) -alkyl (from 1 to 4 carbon atoms) -, R6OC (O) -, or R6OC (O) alkyl (from 1 to 4 carbon atoms) -； Ra1 represents alkyl (from 1 to 4 carbon atoms), hydroxy-alkyl (from 1 to 4 carbon atoms), alkoxy (from 1 to 4 carbon atoms) -alkyl (from 1 to 4 carbon atoms) -, alkyl (from 1 to 4 carbon atoms) -aminoalkyl (from 1 to 4 carbon atoms) -, di- [alkyl (from 1 to 4 carbon atoms)] - amino-alkyl (from 1 to 4 carbon atoms) - , aryl-alkyl (from 1 to 4 carbon atoms) - or R6OC (O) alkyl (from 1 to 4 carbon atoms) -； R2 represents alkyl (from 1 to 6 carbon atoms), cycloalkyl (from 3 to 7 carbon atoms), cycloalkenyl (from 4 to 7 carbon atoms), phenyl, furanyl, thiazolyl, thienyl or pyrazolyl, whose R2 may be unsubstituted or substituted on one to three carbon atoms with Rb substituents, and may also be substituted on a nitrogen atom with alkyl (from 1 to 4 carbon atoms)； each Rb independently represents alkyl (from 1 to 4 carbon atoms), halogen, halo-alkyl (from 1 to 4 carbon atoms), cyano, alkyl (from 1 to 4 carbon atoms) -amino-alkyl (from 1 to 4 4 carbon atoms) -, di- [alkyl (from 1 to 4 carbon atoms)] - amino-alkyl (from 1 to 4 carbon atoms) -, (R6) 2NC (O) alkyl (from 1 to 4 atoms carbon) - or R6OC (O) alkyl (from 1 to 4 carbon atoms) -； X represents O, NH or NMe； or X represents -CH2-O-, wherein the oxygen atom (O) binds to the -C (R4) (R4 ') atom of the ring； each R3 indepe
