GUO, Hongyan,KATO, Darryl,KIRSCHBERG, Thorstens A.,LIU, Hongtae,LINK, John O.,MITCHELL, Michael L.,PARRISH, Jay P.,SQUIRES, Neil,SUN, Jianyu,TAYLOR, James,BACON, Elizabeth M.,CANALES, Eda,CHO, Aesop,C
申请号：
ES15180635
公开号：
ES2646131T3
申请日:
2010.05.12
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of formula: ** Formula ** in which: V is alkyl； L is benzimidazolyl； M is a 5-membered heteroaryl ring； A15 is: ** Formula ** each H14 is independently an unsaturated, partially unsaturated or saturated condensed tricyclic carbocycle that is optionally substituted with one or more groups independently selected from RA1 and RA3； and each XA is independently O, NR, SO, SO2, C (>； = O), NRC (>； = O), C (>； = O) NR, CR>； = CR, NRC (>； = O) NR, alenyl, alkynyl or absent； each R is independently selected from H or alkyl； each RA1 is independently selected from cyano, nitro, SOR4, SO2R4, -alkylSO2R4, haloalkoxy, cyanoalkyl, NR4SO2R4, cycloalkyl, (halo) cycloalkyl, heterocycle, (cycloalkyl) alkyl, (heterocycle) alkyl, wherein each alkyl, heterocycle and cycloalkyl is optionally substituted with one or more halos； each RA3 is independently selected from alkoxy, alkoxyalkyl, alkoxycarbonyl, alkyl, arylalkoxycarbonyl, carboxy, formyl, halo, haloalkyl, hydroxy, hydroxyalkyl, -NRaRb, (NRaRb) alkyl and (NRaRb) carbonyl； Ra and Rb are each independently selected from the group consisting of hydrogen, alkenyl, alkyl, alkylcarbonyl, aryl, arylalkyl, arylalkylcarbonyl, cycloalkyl, cycloalkylalkyl, heterocyclyl and heterocyclylalkyl； each R4 is independently selected from H, alkyl, haloalkyl, aryl and arylalkyl； and each P is independently selected from: ** Formula ** or a pharmaceutically acceptable salt thereof.Un compuesto de fórmula:**Fórmula** en la que: V es alquilo； L es bencimidazolilo； M es un anillo heteroarilo de 5 miembros； A15 es:**Fórmula** cada uno H14 es independientemente un carbociclo tricíclico condensado insaturado, parcialmente insaturado o saturado que está opcionalmente sustituido con uno o más grupos seleccionados independientemente entre RA1 y RA3； y cada XA es independientemente O, NR, SO, SO2, C(>；=O), NRC(>；=O), C(>；=O)NR, CR>；=CR, NRC(>；=O)NR, alenilo, alquinilo o ausente； cada R se selecciona independientemente entre H o alq
