DAL FARRA, Claude,DOMLOGE, Nouha,BOTTO, Jean-Marie
申请号：
ES10715912
公开号：
ES2599781T3
申请日:
2010.04.01
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
Peptide compound of the following general formula (I): R1 - X1 - X2 - Asp - Cys - Arg - X3 - X4 - (AA) p - R2 In which, X1 represents an aspartic acid, a glutamic acid, a serine, a threonine, or is equal to zero, X2 represents an arginine, a leucine, an isoleucine, or is equal to zero, X3 represents an arginine, a lysine, or is equal to zero, X4 represents an arginine, a proline, a histidine , a lysine, or is equal to zero, AA represents any amino acid except cysteine, or one of its derivatives, and p is an integer between 0 and 2, R1 represents the primary amine function of the N-terminal, free or substituted amino acid by a protective group that can be selected from an acetyl group, a benzoyl group, a tosyl group or a benzyloxycarbonyl group, R2 represents the hydroxyl group of the carboxyl function of the C-terminal amino acid, free or substituted by a protective group that can be selected from between a C1 to C20 alkyl chain, or an NH2, NHY or NYY group in which Y represents a C1 to C4 alkyl chain, said general formula sequence (I) being constituted by 3 to 9 amino acid residues, said general formula sequence (I) substitutions may comprise of amino acids X1, X2, X3, and X4 by other chemically equivalent amino acids, where the EDCR peptide, Seq. ID. No. 119 of WO 2007131774.Compuesto peptídico de la siguiente fórmula general (I): R1 - X1 - X2 -Asp - Cys - Arg - X3 -X4 - (AA)p - R2 En la cual, X1 representa un ácido aspártico, un ácido glutámico, una serina, una treonina, o es igual a cero, X2 representa una arginina, una leucina, una isoleucina, o es igual a cero, X3 representa una arginina, una lisina, o es igual a cero, X4 representa una arginina, una prolina, una histidina, una lisina, o es igual a cero, AA representa un aminoácido cualquiera salvo cisteína, o uno de sus derivados, y p es un número entero comprendido entre 0 y 2, R1 representa la función amina primaria del aminoácido N-terminal, libre o sustituida por un grupo protector que puede seleccionarse
