DAL FARRA, CLAUDE,DOMLOGE, NOUHA,BOTTO, JEAN-MARIE
申请号：
ES11794201
公开号：
ES2536119T3
申请日:
2011.11.07
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
General formula peptide (I): R1 (AA) -X1- Arg-X2-Trp-X3-X4-X5-X6 (R3) - (AA) -R2 In which X1 represents aspartic acid or some amino acid, X2 represents glutamine or glutarnic acid, X3 represents asparagine or lysine or glutamine or some amino acid, X4 represents phenylalanine or tyrosine or some amino acid, X5 represents tyrosine or alanine or some amino acid, X6 represents cysteine or some amino acid, AA represents any amino acid except arginine, cysteine, leucine, glycine and glutamic acid, ynyp>； = 0 or 1, with n different from p； R1 represents the primary amine function of the N-terminal amino acid, free or substituted by an acyl type group (R-CO-) where the radical R is either a saturated or unsaturated C1 to C30 alkyl chain, or a aromatic group of benzoyl, tosyl or benzyloxycarbonyl type； R2 represents the carboxyl function of the C-terminal amino acid, which has either a free hydroxyl group or substituted by a group selected from a C1 to C30 alkyl chain, or a -NH2, -NHY or -NYY 'group with Y and Y 'representing a C1 to C4 alkyl chain； R3 represents the thiol function of the cysteine at position X6, be it free, be substituted by a methyl or acetyl group, be covalently linked by a disulfide bridge to another cysteine.Peptido de formula general (I): R1 (AA)-X1- Arg-X2-Trp-X3-X4-X5-X6 (R3) - (AA)-R2 En la cual X1 representa el acido aspartico o algün aminoacido, X2 representa la glutamina o el acido glutarnico, X3 representa la asparagina o la lisina o la glutamina o algun aminoacido, X4 representa la fenilalanina o la tirosina o algun aminoacido, X5 representa la tirosina o la alanina o algun aminoacido, X6 representa la cisteina o algun aminoacido, AA representa cualquier aminoacido excepto la arginina, la cisteina, la leucina, la glicina y el acido glutamico, y n y p>；=0 o 1, con n diferente de p； R1 representa la función amina primaria del aminoacido N-terminal, libre o sustituida por un grupo de tipo acilo (R-CO-) donde el radical R es bien una cadena al
