New oligodextran comprising dextran modified by an amino acid-containing compound, useful for therapeutic and/or prophylactic treatment of diseases in humans or animals
Oligodextran comprising dextran whose polymerization degree is less than 10, modified by at least one amino acid-containing compound (I), is new. Oligodextran comprising dextran whose polymerization degree is less than 10, modified by at least one amino acid-containing compound of formula (-R1-[[AA]-[R2] n] m) (I) with a substitution degree: (j) of 0.01-2.9； and (i) of 0.1-3, is new. AA : amino acid residue located in a backbone of dextran connected to a linker -R1- or optionally bearing a radical -[R2] n； R1 : 1-15C carbon chain comprising optionally substituted heteroatom such as O, N and S or optionally a carboxylic acid function, where R1 forms an amide bond with the amino acid residue [AA], and is directly attached to the backbone of dextran by a connection of the ester, carbamate or ether group； -[R2] noptionally substituted 1-18C carbon chain, where R2 is hydrophobic acid or alcohol； and n, m : 0-2, where the free salifiable functions are in the form of a cation. An independent claim is included for a pharmaceutical composition comprising oligosaccharide and an active ingredient comprising proteins, glycoproteins, peptides and non-peptide therapeutic molecules. ACTIVITY : None given. MECHANISM OF ACTION : None given.L'invention concerne un Oligodextrane, choisi parmi les dextranes dont ie degré de polymérisation moyen est inférieur à 10, modifié par au moins un substituant de formule générale I : -R -[[AA]-[R ] ] Formule I Elle concerne également une composition pharmaceutique caractérisée en ce qu'elle comprend un oligosaccharide selon l'invention et un principe actif est choisi dans le groupe constitué par les protéines, les glycoprotéines, les peptides et les molécules thérapeutiques non-peptidiques.
